Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine

Figure 6

AMP reduced the MBP immune-fluorescent staining in cerebral cortex, corpus callosum and hippocampus. After treating with d-AMP or a same volume of saline for 21 days and subjected to behavioral tests, mice were sacrificed, and their brains were processed for MBP immune-fluorescent staining. Representative photographs were presented and labeled. Quantitative data were statistically analyzed and presented in a bar chart. All AMP-treated mice had decreased values of MBP staining than the average of CNT group. Data were expressed as means ± SEM. Comparisons were made between CNT and AMP groups. *𝑃<0.05; **𝑃<0.01.

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