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Schizophrenia Research and Treatment
Volume 2011 (2011), Article ID 581686, 15 pages
http://dx.doi.org/10.1155/2011/581686
Review Article

Parietal Lobes in Schizophrenia: Do They Matter?

1Department of Neurology, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland
2Psychiatric Outpatient Clinic, University Hospital Basel, 4031 Basel, Switzerland
3Integrierte Psychiatrie Winterthur, Zurich Unterland, 8408 Winterthur, Switzerland

Received 7 June 2011; Revised 28 July 2011; Accepted 10 August 2011

Academic Editor: Hugo Schnack

Copyright © 2011 Murat Yildiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Despite observations that abnormal parietal lobe (PL) function is associated with psychotic-like experiences, our knowledge about the nature of PL involvement in schizophrenia is modest. The objective of this paper is to investigate the role of the PL in schizophrenia. Method. Medline databases were searched for English language publications using the following key words: parietal lobe, combined with schizophrenia, lesions, epilepsy, cognition, rare genetic disorders, MRI, fMRI, PET, and SPECT, respectively, followed by cross-checking of references. Results. Imaging studies in childhood onset schizophrenia suggest that grey matter abnormalities start in parietal and occipital lobes and proceed to frontal regions. Although, the findings are inconsistent, several studies with patients at risk to develop schizophrenia indicate early changes in the PL. Conclusions. We want to propose that in a proportion of individuals with emerging schizophrenia structural and functional alterations may start in the PL and progress to frontal regions.