Table of Contents Author Guidelines Submit a Manuscript
Schizophrenia Research and Treatment
Volume 2012 (2012), Article ID 318535, 3 pages
http://dx.doi.org/10.1155/2012/318535
Editorial

Long-Acting Injectable Antipsychotics in First-Episode Schizophrenia

1Clinic Schizophrenia Program (PEC), Department of Psychiatry, Hospital Clinic of Barcelona, University of Barcelona, 08036 Barcelona, Catalonia, Spain
2Department of Psychiatry, University of Texas Health Science Center San Antonio, 7300 Floyd Curl Drive, San Antonio, TX 78229, USA
3Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town 7500, South Africa
4Klinik und Poliklinic für Psychiatrie und Psychotherapie, Klinikum Rechts der Isar, Technische Universitaet München, Moehlstraße 26, 81675 München, Germany

Received 12 June 2012; Accepted 12 June 2012

Copyright © 2012 Eduard Parellada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. A. Rosenheck, J. H. Krystal, R. Lew et al., “Long-acting risperidone and oral antipsychotics in unstable schizophrenia,” The New England Journal of Medicine, vol. 364, no. 9, pp. 842–851, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Leucht, S. Heres, J. M. Kane, W. Kissling, J. M. Davis, and S. Leucht, “Oral versus depot antipsychotic drugs for schizophrenia—a critical systematic review and meta-analysis of randomised long-term trials,” Schizophrenia Research, vol. 127, no. 1–3, pp. 83–92, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Tiihonen, J. Haukka, M. Taylor, P. M. Haddad, M. X. Patel, and P. Korhonen, “A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia,” American Journal of Psychiatry, vol. 168, no. 6, pp. 603–609, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Heres, T. Reichhart, J. Hamann, R. Mendel, S. Leucht, and W. Kissling, “Psychiatrists' attitude to antipsychotic depot treatment in patients with first-episode schizophrenia,” European Psychiatry, vol. 26, no. 5, pp. 297–301, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. D. I. Velligan, E. Medellin, M. Draper et al., “Barriers to, and strategies for, starting a long acting injection clinic in a community mental health center,” Community Mental Health Journal, vol. 47, no. 6, pp. 654–659, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. T. J. Lambert, J. M. Kane, W. Kissling, and E. Parellada, “CERP-Centres of excellence in relapse prevention. An international educational programme to enhance relapse prevention in schizophrenia,” Schizophrenia Research, vol. 117, no. 2-3, pp. 295–296, 2010. View at Google Scholar
  7. J. M. Kane and C. Garcia-Ribera, “Clinical guideline recommendations for antipsychotic long-acting injections,” The British Journal of Psychiatry, vol. 195, no. 52, pp. S63–S67, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Crivera, Desouza, M. Kozma et al., “Resource utilization in patients with schizophrenia who initiated risperidone long-acting therapy: results from the schizophrenia outcomes utilization relapse and clinical evaluation (SOURCE),” BMC Psychiatry, vol. 11, no. 1, article 168, 2011. View at Google Scholar
  9. N. M. Furiak, H. Ascher-Svanum, R. W. Klein et al., “Cost-effectiveness of olanzapine long-acting injection in the treatment of patients with schizophrenia in the United States: a micro-simulation economic decision model,” Current Medical Research and Opinion, vol. 27, no. 4, pp. 713–730, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. N. R. Schooler, “Relapse and rehospitalization: comparing oral and depot antipsychotics,” Journal of Clinical Psychiatry, vol. 64, supplement 16, pp. 14–17, 2003. View at Google Scholar · View at Scopus
  11. J. P. Lindenmayer, H. Liu-Seifert, P. M. Kulkarni et al., “Medication nonadherence and treatment outcome in patients with schizophrenia or schizoaffective disorder with suboptimal prior response,” Journal of Clinical Psychiatry, vol. 70, no. 7, pp. 990–996, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. J. A. Lieberman, F. P. Bymaster, H. Y. Meltzer et al., “Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection,” Pharmacological Reviews, vol. 60, no. 3, pp. 358–403, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Bartzokis, P. H. Lu, C. P. Amar et al., “Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory,” Schizophrenia Research, vol. 132, no. 1, pp. 35–41, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Gassó, S. Mas, O. Molina, M. Bernardo, A. Lafuente, and E. Parellada, “Neurotoxic/neuroprotective activity of haloperidol, risperidone and paliperidone in neuroblastoma cells,” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 36, no. 1, pp. 71–77, 2012. View at Google Scholar
  15. C. Rabin, Y. Liang, R. S. Ehrlichman et al., “In vitro and in vivo demonstration of risperidone implants in mice,” Schizophrenia Research, vol. 98, no. 1–3, pp. 66–78, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. L. C. Amann, M. J. Gandal, R. Lin, Y. Liang, and S. J. Siegel, “In vitro-in vivo correlations of scalable plga-risperidone implants for the treatment of schizophrenia,” Pharmaceutical Research, vol. 27, no. 8, pp. 1730–1737, 2010. View at Publisher · View at Google Scholar · View at Scopus