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Schizophrenia Research and Treatment
Volume 2012, Article ID 373261, 7 pages
Research Article

Elevated Serum Levels of Homocysteine as an Early Prognostic Factor of Psychiatric Disorders in Children and Adolescents

1Department of Psychiatry and Narcology, Riga Stradins University, 215-27 Maskavas Street, 1019 Riga, Latvia
2Department of Internal Diseases, Riga Stradins University (RSU), 13 Pilsonu Street, 1002 Riga, Latvia
3Children’s Psychiatric Hospital BKUS “Gailezers”, 20 Juglas Street, 1079 Riga, Latvia
4Scientific Laboratory of Molecular Genetics, Riga Stradins University, 16 Dzirciema Street, 1007 Riga, Latvia

Received 21 March 2012; Revised 27 July 2012; Accepted 13 August 2012

Academic Editor: David C. Henderson

Copyright © 2012 Laura Kevere et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Goal. The aim was to examine the serum levels of homocysteine (Hcy) and their associations with the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in patients with schizophrenia and mood disorders as well as controls. Materials and Methods. There were 198 patients: 82 with schizophrenia spectrum disorders, 22 with mood disorders, and 94 controls. The level of Hcy was determined by an isocratic high-performance liquid chromatography system. MTHFR C677T polymorphism was analysed using the restriction fragment length polymorphism-polymerase chain reaction method. Results. The average level of Hcy was μmol/L for patients with schizophrenia, μmol/L for patients with affective disorders, versus μmol/L in a control. The highest level of Hcy has been observed in patients with episodic-recurrent course of schizophrenia ( μmol/L), paranoid schizophrenia continuous ( μmol/L), and in patients with affective disorders ( μmol/L). An association between the MTHFR gene C677T polymorphism and Hcy level was found by linear regression analysis ( , ). Conclusions. The data indicate a link between Hcy levels and schizophrenia and mood disorders. No associations between the level of Hcy in patients with schizophrenia and mood disorders and the MTHFR C677T polymorphism were found.