QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics

Table 1

Baseline demographics and clinical characteristics.

Characteristics	𝑁	% of sample
Gender
Male	118	69.0
Female	53	31.0
Antipsychotic drug naïve	73	42.7
Alcohol use last 6 months
None	33	19.3
Misuse	12	7.0
Illicit drug use last 6 months
None	118	69.0
Misuse	29	17.0
Diagnosis^1
Schz and related	95	57.5
Acute	13	7.9
Drug-induced	21	12.7
Affective	19	11.5
Rest	17	10.2
	Mean	SD/range
Age	34.2	13.9/17–73
PANSS total	73.5	13.7/44–111
PANSS positive	19.7	4.4/11–32
PANSS negative	19.2	7.5/7–39
PANSS general	34.6	6.8/20–56
CDSS	6.9	5.3/0–23
GAF-F	30.9	6.0/10–62
CGI	5.2	0.6/4–6
RBANS, 𝑡-scores	38.3	7.5/20–58

Notes. 𝑁 = number of patients with ECG at baseline and/or ECG at discharge; SD = standard deviation; antipsychotic drug naive = no life-time exposure to antipsychotic drugs before index admission; first admission = index admission was the first admission to a mental hospital; misuse = misuse or dependence according to the Clinical Drug and Alcohol Use Scales (CDUS/CAUS); patients with no illicit drug use could be included in the category alcohol use last 6 months; Schz and related = schizophrenia and related disorders: schizophrenia, schizoaffective disorder, acute polymorphic psychotic disorder with symptoms of schizophrenia, acute schizophrenia-like psychotic disorder, and delusional disorder; acute = acute psychosis other than those categorized under Schz and related; affective = affective psychosis; rest = miscellaneous psychotic disorders. All diagnoses are according to ICD-10; PANSS = the positive and negative syndrome scale; CDSS = the Calgary Depression Scale for Schizophrenia; GAF-F = the Global Assessment of Functioning—Split Version, Functions scale; CGI = the Clinical Global Impression, Severity of Illness scale; RBANS = the repeatable battery for the assessment of neuropsychological status.
¹Patients with missing diagnoses are not included in the list.