QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics

Table 2

Antipsychotic drug use and QTc intervals at discharge/6 weeks.

	Risperidone; 𝑁=25	Olanzapine; 𝑁=31	Quetiapine; 𝑁=18	Ziprasidone; 𝑁=18	Aripiprazole; 𝑁=1
	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)	Mean (SD)
Mean dose (mg/d)	3.5 (1.2)	16.4 (5.9)	457.4 (222.2)	86.7 (39.0)	5.0 (—)
Serum level (nm/L)*	71.6 (47.9)	121.6 (77.7)	501.9 (555.1)	125.3 (99.8)	141 (—)
QTc (ms)	411.3 (24.6)	411.6 (27.0)	412.6 (16.4)	412.5 (19.9)	362.0 (—)

Notes. 𝑁 = number of patients; SD = standard deviation; mg/d = milligrams per day; nm/L = nanomoles per litre; ms = milliseconds.
*Reference ranges: risperidone 30–120; olanzapine 30–200; quetiapine 100–800; ziprasidone 30–200; aripiprazole 200–1300.