Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach

Figure 2

Twenty-four week risperidone treatment increased mice weight and food intake. (a) Effect of risperidone on weight gain in female mice. Differences between both groups appeared significant after 7 weeks of treatment and remained significant at the end of the experiment (24 weeks: control (∘) 24.58±1.21 g versus risperidone (•) 31.33±2.42 g; 𝑃<0.01, 𝑛=24). (b) Effect of risperidone on food intake. Risperidone treatment increased food intake after 13 weeks (Control: 3.90±0.17 g/day/mouse versus Risperidone: 4.43±0.47 g/day/mouse 𝑃<0.05; 𝑛=24).

(a) Weight gain

(b) Food intake