Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders

Table 2

Some examples of repurposed drugs for neuropsychiatric disorders.

Drugs (alphabetic order)	Actions/classes	First intervention	New intervention	References
Amantadine	Anticholinergic-like agent	Influenza	Parkinson’s disease, ADHD	[6, 7]
Amphotericin B	NSAID	Antifungal	Bipolar disorder	[120]
Arbaclofen	GABA agonist	Cerebral palsy	Fragile X syndrome	[116, 121–123]
Atomoxetine	NSRI	Parkinson’s diseases	ADHD	[124]
Dexmecamylamine	Nicotinic receptor modulator	Hypertension	Depression	[125, 126]
Galantamine	Acetylcholinesterase inhibitor	Polio, paralysis	Alzheimer’s disease	[127]
Mecamylamine	Nicotinic receptor antagonist	Hypertension	ADHD; Depression	[128–131]
Mifepristone	Glucocorticoid receptor type II antagonist	Pregnancy termination	Psychotic major depression, Cushing’s syndrome	[132–135]
Ropinirole	D2 agonist	Hypertension	Parkinson’s disease, idiopathic restless leg syndrome	[136–138]
Tamoxifen	Estrogen receptor	Breast tumor	Bipolar disorder; Mania	[139]
Valsartan	Angiotensin receptor blocker	Hypertension	Alzheimer’s disease	[140]

NSAID is nonsteroidal anti-inflammatory drug.
NSRI is norepinephrine-selective reuptake inhibitor.