Review Article

Change in Prolactin Levels in Pediatric Patients Given Antipsychotics for Schizophrenia and Schizophrenia Spectrum Disorders: A Network Meta-Analysis

Table 4

Network meta-analysis results of mean change in prolactin from baseline by patient sex.

Females only

Males onlyPlacebo45.39
(26.02, 64.96)
83.93
(51.04, 117.00)
21.06
(7.11, 34.99)
19.41
(0.83, 37.88)
−1.47 
(−22.03, 19.02)
17.83 
(−1.72, 37.39)
20.09 
(−2.59, 43.13)
19.07
(7.38, 30.93)
Risperidone
1–3 mg/day
38.41
(3.66, 73.84)
24.38
(48.30, 0.35)
−26.03 
(−52.87, 1.00)
46.86
(75.20, 18.82)
27.58
(55.01, 0.15)
−25.30 
(−55.39, 4.43)
29.46
(17.20, 41.73)
10.36 
(−2.01, 22.94)
Risperidone
4–6 mg/day
62.85
(98.96, 27.00)
64.48
(102.70, 26.72)
85.25
(124.90, 46.32)
66.09
(104.50, 27.90)
63.70
(103.40, 24.08)
−2.70 
(−8.97, 3.59)
21.83
(35.26, 8.46)
32.17
(46.08, 18.40)
Quetiapine
400 mg/day
−1.69 
(−17.11, 13.71)
−22.52 
(−47.18, 2.14)
−3.20 
(−27.30, 20.91)
−0.90 
(−27.88, 25.88)
2.81 
(−2.95, 8.54)
16.27
(29.36, 3.18)
26.65
(40.29, 13.13)
5.54 
(−0.04, 11.05)
Quetiapine
800 mg/day
−20.80 
(−48.43, 6.66)
−1.48 
(−28.68, 25.29)
0.67 
(−28.60, 29.87)
3.04 
(−4.82, 10.87)
16.05
(30.30, 2.08)
26.43
(41.22, 11.94)
5.71 
(−4.30, 15.74)
0.23 
(−9.52, 9.86)
Paliperidone
1.5 mg/day
19.32 
(−7.47, 45.84)
21.50 
(−7.73, 50.80)
22.18
(10.88, 33.43)
3.04 
(−13.14, 19.30)
−7.33 
(−23.97, 9.28)
24.87
(11.96, 37.86)
19.35
(6.66, 31.87)
19.16
(6.50, 31.75)
Paliperidone
3–6 mg/day
2.32 
(−25.95, 31.03)
20.61
(9.40, 32.00)
1.54 
(−14.70, 17.62)
−8.87 
(−25.30, 7.58)
23.35
(10.46, 36.24)
17.82
(5.19, 30.41)
17.59
(4.98, 30.30)
−1.52 
(−16.40, 13.56)
Paliperidone
6–12 mg/day

The results of the fixed effects NMA are displayed. Data are presented as mean difference (95% credible interval). Values correspond to the mean differences in the column versus the row for the upper triangle and the mean differences in the row versus the column for the lower triangle. Values in bold are those differences that are statistically important.