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Schizophrenia Research and Treatment
Volume 2019, Article ID 5601249, 5 pages
Research Article

Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine

1Departamento de Psiquiatría, Escuela de Medicina, Universidad de Valparaíso, Chile
2Escuela de Química y Farmacia, Facultad de Farmacia, Universidad de Valparaíso, Chile
3Centro de Investigación Farmacopea Chilena, Universidad de Valparaíso, Chile
4Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Chile
5Departamento de Psiquiatría y Salud Mental Norte, Programa de Genética Humana, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Chile
6Centro Interdisciplinario de Neurociencia de Valparaíso CINV, Universidad de Valparaíso, Chile

Correspondence should be addressed to Alvaro Cavieres; moc.liamg@oravla.sereivac and Pablo R. Moya;

Received 27 March 2019; Revised 4 June 2019; Accepted 8 June 2019; Published 25 June 2019

Academic Editor: Hugo Schnack

Copyright © 2019 Alvaro Cavieres et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alterations in neuroinflammatory processes have been suggested to contribute to the development of Schizophrenia (SZ); one component of the inflammatory system that has been linked to this disorder is interleukin-6 (IL-6). The minor allele of rs2228145, a functional polymorphism in the IL-6 receptor gene, has been associated to elevated IL-6 plasma levels and increased inflammatory activity, making it an interesting candidate to study as a possible factor underlying clinical heterogeneity in SZ. We studied a sample of 100 patients undergoing treatment with clozapine. Their symptoms were quantified by Brief Psychotic Rating Scale; those with the lowest scores (“remitted”) were compared with the highest (“clozapine treatment resistant”). We determined allelic frequencies for rs2228145 and IL-6 plasma levels. Our results do not support a role of IL-6 in response to treatment with clozapine. Further studies accounting for potential confounding factors are necessary.