Homocysteine in Schizophrenia: Independent Pathogenetic Factor with Prooxidant Activity or Integral Marker of Other Biochemical Disturbances?

Table 1

Markers of oxidative stress in patient and healthy control groups.

Parameter	Patients ()	Healthy ()	Mann–Whitney test; /Benjamini-Hohberg adjusted
GSH, μMol/l: , Me (Q1, Q3)	; 923.5 (798, 1047)	; 1002 (898.5, 1075.5)	; /
SOD activity, units of activity/g Hb: , Me (Q1, Q3)	; 164.5 (137, 219)	; 180 (138.5, 223)	; /
CAT activity, units of activity/g Hb: , Me (Q1, Q3)	; 41.5 (17, 70)	; 60.0 (40.5, 93.0)	; /
КDNPH, spontaneous oxidation (units optical density/mg protein/ml): , Me (Q1, Q3)	; 0.11 (0.10, 0.13)	; 0.090 (0.08, 0.10)	; /
ADNPH, spontaneous oxidation (units optical density/mg protein/ml): , Me (Q1, Q3)	; 0.080 (0.060, 0.090)	, 0.070 (0.050, 0.080)	; /
КDNPH, metal-catalyzed oxidation (units optical density/mg protein/ml): , Me (Q1, Q3)	; 0.49 (0.45, 0.53)	; 0.48 (0.44, 0.53)	; /
АDNPH, metal-catalyzed oxidation (units optical density/mg protein/ml): , Me (Q1, Q3)	; 0.46 (0.43, 0.51)	; 0.44 (0.39, 0.53)	; /
MDA, nmol/ml: , Me (Q1, Q3)	; 3.15 (2.92, 4.05)	; 3.21 (2.65, 3.71)	; /

Note: GSH: reduced glutathione; SOD: superoxide dismutase; CAT: catalase; КDNPH: ketone-2,4-dinitrophenylhydrazones; АDNPH: aldehyde-2,4-dinitrophenylhydrazones; MDA: malonic dialdehyde; Me (Q1, Q3): median and interquartile range; “”: .