Table of Contents
SRX Pharmacology
Volume 2010, Article ID 715414, 4 pages
Clinical Study

Sustain Released Bupropion in the Treatment of Tricotillomania: Outpatient Follow Up Survey

Research Department, The Beer Yaakov Mental Health Center, Beer Yaakov, P.O. Box 1, 70350, Israel

Received 15 October 2009; Accepted 24 November 2009

Copyright © 2010 Pinhas N. Dannon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Tricotillomania (TTM) is more common than expected. SSRI's are the treatment of choice in TTM. However, response rates are lower with SSRI's. The aim of our study is to explore other pharmacological interventions. Materials and Methods. Nine female TTM patients with SSRI treatment failure were included. Sample was treated with bupropion SR up to 450 mg/day. Results. Six out of nine patients responded well to bupropion SR. Massachusetts General Hospital Hair Pulling Scale (MGH) demonstrated a significant improvement at the twelve week point (f: 32.3, power: 1, lambda: 97.1, P<.0001) and the response rates remained stable at sixteen-month follow up visit. Conclusions. Bupropion SR could be an alternative pharmacological treatment for TTM. Larger samples with double blind placebo controlled design are needed to confirm our preliminary report.