Table of Contents
Scholarly Research Exchange
Volume 2008, Article ID 137091, 4 pages
Research Article

A Novel and Efficient Synthesis of Intermediates for the Preparation of Fexofenadine

1College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Xiasha Campus, Hangzhou, Zhejiang 310036, China
2Analytical Center, Zhejiang University, Xixi Campus, Hangzhou, Zhejiang 310036, China

Received 22 April 2008; Accepted 26 June 2008

Copyright © 2008 Jiangang Mao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient and environmentally friendly synthetic approach for the preparation of fexofenadine was developed. The method involves hydrogenation and oxygenation reaction and has good atom utilization, all the starting material is nontoxic.