Table of Contents
Scholarly Research Exchange
Volume 2008 (2008), Article ID 434329, 5 pages
http://dx.doi.org/10.3814/2008/434329
Research Article

New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines

Organic Chemistry Research Center, Department of Chemistry, KTHM College, Gangapur Road, Nashik 422002, India

Received 1 March 2008; Accepted 13 August 2008

Copyright © 2008 Raghunath B. Toche et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α-acetyl-γ-butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.