Table of Contents
Scholarly Research Exchange
Volume 2009 (2009), Article ID 657042, 5 pages
http://dx.doi.org/10.3814/2009/657042
Research Article

Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer

Department of Molecular Medicine (MOMA), Center for Molecular Clinical Cancer Research (CMCC), Aarhus University Hospital/Skejby, Brendstrupgaardsvej 100, Aarhus N, Denmark

Received 1 January 2009; Revised 3 May 2009; Accepted 20 May 2009

Copyright © 2009 Francisco Mansilla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microarray gene expression profiling comprising 168 colorectal adenocarcinomas and 10 normal mucosas showed that over 79% of the genes involved in human ribosome biogenesis are significantly upregulated (log2>0.5, p<103) when compared to normal mucosa. Overexpression was independent of microsatellite status. The promoters of the genes studied showed a significant enrichment for several transcription factor binding sites. There was a significant correlation between the number of binding site targets for these transcription factors and the observed gene transcript upregulation. The upregulation of rRNA processing genes points towards a coordinated process enabling the overproduction of matured ribosomal structures.