Contralateral Prophylactic Mastectomy among Women with Pathogenic Variants in BRCA1/2: Overall Survival, Racial, and Ethnic Differences

Table 3

Adjusted and unadjusted cox regression model for overall survival.

Parameter	Level	Total N	N died	Univariate model			Multivariable model
				HR	95% CI	value	HR	95% CI	value
Age at diagnosis	Continuous	144	24	0.99	0.95–1.04	0.72	1.00	0.96–1.05	0.87
Diagnosis year	Continuous	144	24	1.22	1.05–1.43	0.01	1.12	0.95–1.33	0.18
Marital status	Married	103	15	Ref		0.31
	Other	41	9	1.56	0.68–3.56
Education	<High school	29	6	Ref		0.40
	≥ High school	102	15	0.66	0.36–1.70
Race	Nonwhites	30	8	Ref		0.06	Ref		0.04
	Whites	114	16	0.41	0.18–0.97		0.39	0.16–0.97
Family history of breast cancer	No	72	11	Ref		0.66	Ref		0.44
	Yes	70	13	1.20	0.54–2.67		0.71	0.29–1.71
Family history of ovarian cancer	No	123	21	Ref		0.79	Ref		0.54
	Yes	19	3	0.85	0.25–2.87		0.65	0.16–2.57
Stage	I	42	4	Ref		0.04	Ref		0.10
	II	70	10	1.59	0.50–5.07		1.51	0.45–5.10
	III	32	10	3.82	1.20–12.19		3.41	0.98–11.90
Nodal status	Node 0	71	10	Ref		0.58
	Node 1	45	7	1.16	0.44–3.03
	Node 2	12	3	2.12	0.58–7.71
	Node 3	16	4	1.94	0.61–6.19
CPM	No	63	12	Ref		0.43	Ref		0.58
	Yes	81	12	0.73	0.33–1.62		0.79	0.34–1.82
HR status	ER−/PR−	71	15	Ref		0.16	Ref		0.14
	ER+ or PR+	72	9	0.56	0.25–1.29		0.50	0.20–1.25
HER2/neu status	Negative	125	23	Ref		0.11	Ref		0.28
	Positive	17	1	0.27	0.04–2.00		0.33	0.04–2.50

HR: hormone receptor; CPM: contralateral prophylactic mastectomy; HR: hazard ratio.