Research Article
Contralateral Prophylactic Mastectomy among Women with Pathogenic Variants in BRCA1/2: Overall Survival, Racial, and Ethnic Differences
Table 3
Adjusted and unadjusted cox regression model for overall survival.
| Parameter | Level | Total N | N died | Univariate model | Multivariable model | HR | 95% CI | value | HR | 95% CI | value |
| Age at diagnosis | Continuous | 144 | 24 | 0.99 | 0.95–1.04 | 0.72 | 1.00 | 0.96–1.05 | 0.87 |
| Diagnosis year | Continuous | 144 | 24 | 1.22 | 1.05–1.43 | 0.01 | 1.12 | 0.95–1.33 | 0.18 |
| Marital status | Married | 103 | 15 | Ref | 0.31 | | Other | 41 | 9 | 1.56 | 0.68–3.56 |
| Education | <High school | 29 | 6 | Ref | 0.40 | | ≥ High school | 102 | 15 | 0.66 | 0.36–1.70 |
| Race | Nonwhites | 30 | 8 | Ref | 0.06 | Ref | 0.04 | Whites | 114 | 16 | 0.41 | 0.18–0.97 | 0.39 | 0.16–0.97 |
| Family history of breast cancer | No | 72 | 11 | Ref | 0.66 | Ref | 0.44 | Yes | 70 | 13 | 1.20 | 0.54–2.67 | 0.71 | 0.29–1.71 |
| Family history of ovarian cancer | No | 123 | 21 | Ref | 0.79 | Ref | 0.54 | Yes | 19 | 3 | 0.85 | 0.25–2.87 | 0.65 | 0.16–2.57 |
| Stage | I | 42 | 4 | Ref | 0.04 | Ref | 0.10 | II | 70 | 10 | 1.59 | 0.50–5.07 | 1.51 | 0.45–5.10 | III | 32 | 10 | 3.82 | 1.20–12.19 | 3.41 | 0.98–11.90 |
| Nodal status | Node 0 | 71 | 10 | Ref | 0.58 | | Node 1 | 45 | 7 | 1.16 | 0.44–3.03 | Node 2 | 12 | 3 | 2.12 | 0.58–7.71 | Node 3 | 16 | 4 | 1.94 | 0.61–6.19 |
| CPM | No | 63 | 12 | Ref | 0.43 | Ref | 0.58 | Yes | 81 | 12 | 0.73 | 0.33–1.62 | 0.79 | 0.34–1.82 |
| HR status | ER−/PR− | 71 | 15 | Ref | 0.16 | Ref | 0.14 | ER+ or PR+ | 72 | 9 | 0.56 | 0.25–1.29 | 0.50 | 0.20–1.25 |
| HER2/neu status | Negative | 125 | 23 | Ref | 0.11 | Ref | 0.28 | Positive | 17 | 1 | 0.27 | 0.04–2.00 | 0.33 | 0.04–2.50 |
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HR: hormone receptor; CPM: contralateral prophylactic mastectomy; HR: hazard ratio.
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