Survival Outcomes of Breast-Conserving Therapy versus Mastectomy in Early-Stage Breast Cancer, Including Centrally Located Breast Cancer: A SEER-Based Study
Table 6
Multivariate survival analysis of prognostic factors among CLBC patients.
Cox-OS
Cox-BCSS
Fine–Gray
CS
HR
95% CI
-value
HR
95% CI
-value
HR
95% CI
-value
HR
95% CI
-value
Year of diagnosis
<0.001
<0.001
2000–2003 vs. 2008–2015
1.329
1.194–1.479
<0.001
2.005
1.715–2.344
<0.001
1.629
1.395–1.903
< 0.001
1.536
1.315–1.795
<0.001
2004–2007 vs. 2008–2015
1.134
1.016–1.265
0.025
1.441
1.226–1.693
<0.001
1.310
1.114–1.541
0.001
1.267
1.078–1.488
0.004
Age, years
< 0.001
<0.001
64–72 vs. 18–63
2.437
2.200–2.700
<0.001
1.757
1.514–2.039
<0.001
1.380
1.183–1.609
< 0.001
1.482
1.274–1.724
<0.001
73–79 vs. 18–63
4.904
4.419–5.441
<0.001
3.258
2.763–3.843
<0.001
1.611
1.347–1.927
< 0.001
2.004
1.685–2.383
<0.001
Race
<0.001
<0.001
Black vs. white
1.213
1.056–1.393
0.006
1.263
1.038–1.538
0.020
1.174
0.952–1.447
0.133
1.175
0.965–1.431
0.109
Others vs. white
0.683
0.579–0.805
< 0.001
0.703
0.558–0.885
0.003
0.766
0.606–0.968
0.025
0.739
0.587–0.931
0.010
Histology type
ILC vs. IDC
–
–
0.627
–
–
0.351
–
–
0.576
–
–
0.527
Laterality
Right vs. left
–
–
0.119
0.855
0.756–0.966
0.012
0.860
0.759–0.975
0.018
0.860
0.761–0.972
0.016
Grade
< 0.001
<0.001
II vs. I
1.207
1.068–1.364
0.003
2.616
1.964–3.486
<0.001
2.651
1.993–3.526
<0.001
2.658
1.994–3.542
<0.001
III/IV vs. I
1.436
1.255–1.642
<0.001
3.435
2.567–4.596
<0.001
3.399
2.521–4.583
<0.001
3.426
2.549–4.604
<0.001
T stage
<0.001
<0.001
T1b vs. T1a
1.081
0.866–1.350
0.490
0.834
0.555–1.254
0.384
0.838
0.561–1.251
0.386
0.842
0.560–1.266
0.408
T1c vs. T1a
1.463
1.194–1.793
<0.001
1.348
0.947–1.920
0.097
1.262
0.891–1.788
0.191
1.303
0.913–1.859
0.145
T2 vs. T1a
2.086
1.697–2.563
<0.001
2.398
1.690–3.403
<0.001
2.196
1.553–3.105
< 0.001
2.312
1.625–3.291
<0.001
N stage
<0.001
<0.001
N1 vs. N0
1.455
1.322–1.602
<0.001
1.859
1.613–2.141
<0.001
1.901
1.636–2.209
<0.001
1.939
1.678–2.242
<0.001
N2 vs. N0
2.491
2.129–2.914
<0.001
3.847
3.141–4.712
<0.001
3.776
3.037–4.696
<0.001
3.969
3.231–4.875
<0.001
N3 vs. N0
4.567
3.763–5.541
<0.001
7.081
5.603–8.949
<0.001
6.353
4.897–8.242
<0.001
6.853
5.411–8.680
<0.001
ER
Positive vs. negative
0.824
0.719–0.945
0.005
—
—
0.099
—
—
0.344
—
—
0.214
PR
Positive vs. negative
0.851
0.763–0.949
0.004
0.625
0.550–0.711
<0.001
0.641
0.543–0.757
<0.001
0.644
0.549–0.755
<0.001
Treatment
BCT vs. mastectomy
0.734
0.672–0.802
<0.001
0.660
0.576–0.755
<0.001
0.709
0.617–0.815
<0.001
0.686
0.598–0.786
<0.001
Chemotherapy
Yes vs. no or unknown
0.765
0.695–0.843
<0.001
—
—
0.381
—
—
0.809
—
—
0.699
CLBC, centrally located breast cancer; HR, hazard ratio; CI, confidence interval; ILC, invasive lobular carcinoma; IDC, invasive ductal carcinoma; ER, estrogen receptor; PR, progesterone receptor; BCT, breast-conserving therapy.
