The Breast Journal

Review Article

Factors Associated with Late Local Radiation Toxicity after Post-Operative Breast Irradiation

Table 3

Overview of different domains of late radiation toxicity in relation to the summarized risk factors.
 StudyRadiotherapySurgery and systemic treatmentPatient characteristicsOthera
Increased dose or irradiated volumeRT boost (dose)Acute toxicityRT- surgery intervalSurgical complicationsALNDEndocrine therapyChemotxOther LRT symptomsAgeBreast volumeTumor locationBMIDiabetes mellitus
GRTCiamellaS/NSbS/NSb——NS——S/NSb—NSNS——NSNS
de roseS——————————————
de rose (2020)NSS————NSNS—NSS———S
DigesuS—————NSNS—————NS/ScS
HannanS—————————S—S—S
Hosni—————————SNS——S—
KellerSS————SS———————
LazzariS——————NS——NS———S
Palumbo—NS———NSNSNS—————NSNS
Yu—NS——S————NS——NS—S/NS
PainBarnett—SS—S————S—————
de rose (2020)—NS————————NS———NS
Hille-betzNS———————S——————
Ishiyama—S—NS———NS—NS—NS——NS
Breast fibrosisBergom—NS———NS—NS——NS—NS—NS
BronsartS/NS——————NS—NSNS————
de santisNSNS—————NS——NS——NS—
Hille-betzNS——S———NS——S————
Ishiyama—NS—S———NS—NS—NS——NS
Joseph——————NSNSNSNSS———NS
KelemenS————S——S—————S
Lilla—————————S————S
MeattiniNSS————————S———S/NS
La rocca—S—————NS—NS—————
Breast or arm edemaBarnett—SS——————SS————
Hille-betzNS——NS—S————S—NS—NS
Ishiyama—NS—NS———S—NS—S——NS
KelemenS————S—————————
KellerSS————SS———————
MeattiniSS/NSc————————NS———NS
La rocca—S———————NS————NS
aDepending on boost/no boost group. bDepending on subacute or skin toxicity respectively. cDepending on administered dose; Abbreviations: BMI body mass index; Chemotx chemotherapy; GRT late radiation toxicity; LRT late radiation toxicity; NS no significant association, RT radiotherapy; S significant association; Association not studied.