Thrombosis

Review Article

Thrombin A-Chain: Activation Remnant or Allosteric Effector?

Table 1

Prothrombin A-chain sequence alignment across 11 vertebrate species. NCBI CDD Pfam09396 [12]. In the third column, conserved residues are shown in regular font, and nonconserved residues are marked in italic font. 12 human prothrombin A-chain residues interact with the B-chain and are shown underlined. Human prothrombin numbering is provided underneath the sequences.
SpeciesCommon nameA-chain sequence
Homo sapiensHumanTATSEYQTFFNPRTFGSGEADCG LRPLFEKKSLE DK T ERELLESYI DGR
Mus musculusMouseTTDAEFHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDGR
Rattus norvegicusNorway ratTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGR
Bos TaurusCowTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGR
Elaphe sp.ElephantTTIQQHETFFDPKTFGEGEADCGIRPLFEKKKISDSTENELLESYLQGR
Gallus gallusChickenTIFQEFKTFFDEKTFGEGEADCGTRPLFEKKQITDQSEKELMDSYMGGR
Struthio camelusOstrichTVLQEYKTFFDDKTFGSGEADCGIRPLFEKKKIKDKSEKELLESYIGSR
Crocodylus niloticusNile crocodileTSIPEYKVFFDPKTFGSGEADCGIRPLFEKKNIADKTEKDLLESYIEGR
Danio rerioZebra fishTTLDQRKAFFNPRSFGNGELDCGERPLFEKINKADKNEKELLMSYTGSR
Oncorhynchus mykissRainbow troutTLSGPRQSFFSPQSFGSGELVCRERPMFEKMSKKDGREQELIDSYQGGR
Tetraodon nigroviridisPuffer fishTTLSSRKQFFNPRTFGQGENDCGQRPLFEKISKKDAKEDELLESYREKR
Xenopus laevisAfrican clawed frogTTTEEHQTFFDEKTFGSGEAVCGLRPLFEQKSVEDKGEKELMESYMQGR
         Human prothrombin numbering:272   282   292   302   312