Thrombocytosis: Diagnostic Evaluation, Thrombotic Risk Stratification, and Risk-Based Management Strategies

Table 1

Causes of thrombocytosis (adapted from Harrison et al.).

Clonal	Reactive	Spurious
Essential thrombocythemia	Infection	Microspherocytes
Polycythemia vera	Inflammation	Cryoglobulinemia
Primary myelofibrosis	Tissue damage	Neoplastic cell fragments
Myelodysplasia with del (5q)	Hyposplenism	Schistocytes
Refractory anemia with ringed	Post-operative	Bacteria
sideroblasts associated with
marked thrombocytosis (RARS-T)
Chronic myeloid leukemia	Iron deficiency
Chronic myelomonocytic leukemia	Malignancy
Atypical chronic myeloid leukemia	Hemolysis
MDS/MPN-U	Drug effect
POEMS syndrome	“Rebound” following myelosuppression
Familial thrombocytosis