Table of Contents
Volume 2011, Article ID 981497, 4 pages
Clinical Study

Treatment of Deep Vein Thrombosis with Continuous IV Infusion of LMWH: A Retrospective Study in 32 Children

1Department of Clinical Haematology, Centre for Thrombosis and Haemostasis. Children's University Hospital, Masaryk University, 62500 Brno, Czech Republic
2Institute of Biostatistics and Analyses, Masaryk University, 62500 Brno, Czech Republic

Received 21 July 2010; Revised 14 January 2011; Accepted 12 February 2011

Academic Editor: Domenico Prisco

Copyright © 2011 Veronika Fiamoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thirty-two consecutive children aged 0–18 years with VTE treated with LMWH administered as a continuous infusion (CI) were identified at the Children's University Hospital Brno. The treatment led to at least partial resolution of the thrombus within two weeks in 85% of patients. There were no adverse events or increased bleeding reported in any patients. No recurrences were observed during a followup period of 6 months. Although continuous infusion should not replace subcutaneous (SC) administration of LMWH, CI appeared to be safe and efficient and may provide an alternate method of administering LMWH in a subset of the paediatric population where SC administration may not be feasible. Further prospective studies are needed to support the promising findings of our pilot clinical observation.