Table of Contents
Volume 2012, Article ID 156397, 6 pages
Review Article

Experimental Validation of Methods for Prophylaxis against Deep Venous Thrombosis: A Review and Proposal

1Theoretical Medicine and Biology Group, 26 Castle Hill, Glossop, Derbyshire, UK
2Department of Pathology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
3Centre for Comparative and Clinical Anatomy, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK

Received 2 December 2011; Revised 20 January 2012; Accepted 6 February 2012

Academic Editor: Debra A. Hoppensteadt

Copyright © 2012 Paul S. Agutter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The experimental procedure by which the valve cusp hypoxia (VCH) hypothesis of the etiology of deep venous thrombosis (DVT) was confirmed lends itself to testing of methods of prophylaxis. Similar animal experiments could end the present exclusive reliance on statistical analysis of data from large patient cohorts to evaluate prophylactic regimes. The reduction of need for such (usually retrospective) analyses could enable rationally-based clinical trials of prophylactic methods to be conducted more rapidly, and the success of such trials would lead to decreased incidences of DVT-related mortality and morbidity. This paper reviews the VCH hypothesis (“VCH thesis”, following its corroboration) and its implications for understanding DVT and its sequelae, and outlines the experimental protocol for testing prophylactic methods. The advantages and limitations of the protocol are briefly discussed.