Table of Contents
Volume 2012, Article ID 219389, 8 pages
Research Article

Pathological Perspective of Drug-Eluting Stent Thrombosis

Department of Laboratory Medicine, Kokura Memorial Hospital, 3-2-1 Asano, Kokurakita-ku, Kitakyushu, Kokura 802-8555, Japan

Received 25 November 2011; Accepted 7 March 2012

Academic Editor: Juan F. Granada

Copyright © 2012 Katsumi Inoue. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although very late stent thrombosis (VLST) after drug-eluting stent (DES) implantation remains a major concern, the precise mechanisms have not been clarified. An association between late acquired incomplete stent apposition (ISA) and VLST of DES has been suggested by several intravascular ultrasound studies demonstrating very high prevalence of ISA in the setting of VLST. To clarify the pathological mechanisms of VLST, we investigated vascular responses of coronary arteries of VLST cases after DES implantation.