Table of Contents
Thrombosis
Volume 2012, Article ID 306263, 4 pages
http://dx.doi.org/10.1155/2012/306263
Clinical Study

Evaluation of RANKL/OPG Serum Concentration Ratio as a New Biomarker for Coronary Artery Calcification: A Pilot Study

1Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9188865531, Iran
2Pharmaceutical Research Center, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad 9188865531, Iran
3Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9188865531, Iran
4Department of Cardiovascular Diseases, Razavi Hospital, 9148857114, Iran
5Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad 9188865531, Iran

Received 12 November 2011; Revised 20 January 2012; Accepted 24 January 2012

Academic Editor: Giovanni de Gaetano

Copyright © 2012 Amir Hooshang Mohammadpour et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. There is a strong need for biomarkers to identify patients at risk for future cardiovascular events related with progressive atherosclerotic disease. Osteoprotegerin (OPG) protects the skeleton from excessive bone resorption by binding to receptor activator of nuclear factor- B ligand (RANKL) and preventing it from binding to its receptor, receptor activator of nuclear factor- B. However, conflicting results have been obtained about association of serum level of OPG or RANKL with coronary artery disease (CAD). Based on their role in inflammation and matrix degradation and the fact that atherosclerotic plaque formation is an inflammatory process, we hypothesized that RANKL : OPG ratio could be a better biomarker for CAD. Methods. In this cross-sectional study, the correlation between RANKL : OPG ratio serum concentration and coronary artery calcification (CAC) in 50 patients with ischemic coronary disease has been investigated. We used ELISA method for measuring RANKL and OPG serum concentrations. Results. There was a significant correlation between RANKL : OPG serum concentration ratio and CAC in our study population ( ). Conclusion. Our results suggested that RANKL : OPG ratio concentration has a potential of being used as a marker for coronary artery disease.