Table of Contents
Thrombosis
Volume 2012, Article ID 594986, 10 pages
http://dx.doi.org/10.1155/2012/594986
Review Article

Factor V Leiden and Inflammation

1Servicio de Hemoterapia y Hemostasia, Hospital Clínic, C/Villarroel 170, 08036 Barcelona, Spain
2Molecular Imaging Program, National Cancer Institute, 10 Center Drive, Building 10, Room B3B85, Bethesda, MD 20892, USA

Received 5 January 2012; Accepted 6 February 2012

Academic Editor: Nejat Akar

Copyright © 2012 Silvia Perez-Pujol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible role of FVL in inflammatory conditions known to be present in different disorders such as uremia, cirrhosis, liver transplantation, depression as well as sepsis, infection or, inflammatory bowel disease (IBD). Whether platelet FVL will increase the activation of coagulation and/or in which proportion is able to determine the final outcome in the previously mentioned inflammatory conditions is a subject that remains uncertain. This paper will review the association of FVL with inflammation. Specifically, it will analyze the important role of the endothelium and the contribution of other inflammatory components involved at both the immune and vascular levels. This paper will also try to emphasize the importance of being a FVL carrier in associations to diseases where a chronic inflammation occurs, and how this condition may be determinant in the progression and outcome of a specific clinic situation.