The Role of Dermcidin Isoform 2: A Two-Faceted Atherosclerotic Risk Factor for Coronary Artery Disease and the Effect of Acetyl Salicylic Acid on It

Table 1

Correlation between plasma dermcidin level and systolic and diastolic pressures in normotensive and hypertensive subjects.

Normotensive subjects					Hypertensive subjects
Parameters	Dermcidin(pmol/mL)	Systolic blood pressure (mm of Hg)	Diastolic blood pressure (mm of Hg)	NO (nmol/h)	Dermcidin(pmol/mL)	Systolic blood pressure (mm of Hg)	Diastolic blood pressure (mm of Hg)	NO (nmol/h)
Range	0–24	115–130	75–85	4.0±1.4	43.1–175	150–180	85–110	0.4±0.19
Median	5	125	80		98	160	90

“Pearson 𝑟” (correlation coefficient) = + 0.922 and + 0.844 between dermcidin level and systolic and diastolic pressures, respectively, in normotensive subjects.
“Pearson 𝑟" (correlation coefficient) = + 0.924 and + 0.909 between dermcidin level and systolic and diastolic pressures, respectively, in hypertensive subjects.
The significance (𝑃 value) was 𝑃 < 0.0001 between dermcidin levels, systolic and diastolic pressures in the normotensive and hypertensive subjects as determined by the Mann Whitney 𝑈 test with the medians significantly different.
Blood samples were collected from both normotensive and hypertensive subjects (𝑛=74 in each group) by venipuncture as described in Section 2. The plasma dermcidin level was determined by ELISA by using electrophoretically purified dermcidin as described. The blood pressures were determined by sphygmomanometer at presentation.