Thrombosis / 2013 / Article / Tab 1

Review Article

Prevention and Treatment of Venous Thromboembolism with New Oral Anticoagulants: A Practical Update for Clinicians

Table 1

Limitations of traditional anticoagulants.

 Narrow therapeutic window
 Unpredictable pharmacokinetic and pharmacodynamic properties
 Significant interaction with food and drugs
 Slow onset and offset of action
 Need for regular anticoagulation monitoring and dose adjustment
 High incidence of intracranial bleeding, especially among Asian patients
 Parenteral administration only
 Risk of thrombocytopenia
 Need for laboratory monitoring (platelet count)

UFH: unfractionated heparin, LMWH: low molecular weight heparin.