Table of Contents
Thrombosis
Volume 2013, Article ID 948765, 10 pages
http://dx.doi.org/10.1155/2013/948765
Review Article

Regulation of Vascular Function on Posttranscriptional Level

Charit-Universitätsmedizin Berlin, CCM, Institut of Clinical Pharmacology and Toxicology Berlin, Charite Platz 1, 10117 Berlin, Germany

Received 9 July 2013; Accepted 17 September 2013

Academic Editor: Omer Iqbal

Copyright © 2013 Andreas Eisenreich. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Posttranscriptional control of gene expression is crucial for regulating plurality of proteins and functional plasticity of the proteome under (patho)physiologic conditions. Alternative splicing as well as micro (mi)RNA-mediated mechanisms play an important role for the regulation of protein expression on posttranscriptional level. Both alternative splicing and miRNAs were shown to influence cardiovascular functions, such as endothelial thrombogenicity and the vascular tone, by regulating the expression of several vascular proteins and their isoforms, such as Tissue Factor (TF) or the endothelial nitric oxide synthase (eNOS). This review will summarize and discuss the latest findings on the (patho)physiologic role of alternative splicing processes as well as of miRNAs on modulation of vascular functions, such as coagulation, thrombosis, and regulation of the vascular tone.