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Tuberculosis Research and Treatment
Volume 2010, Article ID 406346, 6 pages
http://dx.doi.org/10.1155/2010/406346
Clinical Study

The Soluble Plasminogen Activator Receptor as a Biomarker on Monitoring the Therapy Progress of Pulmonary TB-AFB(+) Patients

1Laboratory of Biochemistry-Molecular Biology, Faculty of Medicine, Brawijaya University, Malang 65145, Indonesia
2Department of Pulmonology, Faculty of Medicine, Brawijaya University Malang-Dr. Saiful Anwar Hospital Malang, Malang 65145, Indonesia

Received 29 June 2010; Accepted 8 September 2010

Academic Editor: William N. Rom

Copyright © 2010 Tri Yudani Mardining Raras and Iin Noor Chozin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The role of soluble soluble urokinase-type plasminogen activator receptor (suPAR) as a biological marker for TB treatment efficacy on active pulmonary TB-AFB(+) patients was investigated. Twenty pulmonary TB-AFB(+) patients participated in a cohort study for six months. The plasma suPAR level was measured using ELISA method before treatment, two months, four months and six months after treatment. At the same time clinical parameters were also measured. Results indicated that all patients ( 𝑛 = 2 0 ) showed highest plasma suPAR levels before treatment (median 12.775 ng/mL) and significantly decreased ( 𝑃 = . 0 0 0 1 <.05, 𝑅 2 = . 8 9 0 ) after 2 months (median 8.019 ng/mL) and 4 months (median 5.771 ng/mL) of treatment, respectively. However, only slightly declined after 6 months therapy (median 5.009 ng/mL), near control group level (median 4.772 ng/mL). Interestingly, the significant reduced of suPAR level was parallel to treatment efficacy and correlated with other clinical and laboratory parameters, that is, decreasing of patients' complaints, increasing of BMI ( 𝑟 = 0 . 2 8 1 ), thoracic imaging improvement, sputum conversion, decreasing of ESR ( 𝑟 = 0 . 5 7 7 ) and monocytes count ( 𝑟 = 0 . 5 3 6 ) with exception the width of lesion in thoracic imaging. In conclusion, the suPAR level in could reflect the progress of TB therapy.