Clinical Evaluation of Efficacy of ^99mTC -Ethambutol in Tubercular Lesion Imaging

Table 3

Comparison of pharmacokinetic parameters of ${}_{}{}^{99m}T$c-EMB and unlabeled EMB.

${}_{}{}^{99\text{m}}\text{T}$c-EMB	Unlabeled ${}_{}{}^{99\text{m}}\text{T}$c-EMB
${\text{T}}_{1/2}$ = 9.5 hours	${\text{T}}_{1/2}\mathrm{\hspace{0.17em}\hspace{0.17em}}$ = 10–15 hours
$V_d$ = 2.8 L/Kg	$V_d$ = 3.1 L/Kg
Cl = 16.5 ml/hr	Cl = 15–20 ml/hr
Plasma protein binding = 60%	Plasma protein binding = 10%–40%

Where, $T_{1/2}$ is half-life, $V_d$ is volume of distribution, and Cl is clearance.