Mycobacterium tuberculosis Complex Genotype Diversity and Drug Resistance Profiles in a Pediatric Population in Mexico

Table 4

Description of shared types representing clustered strains and their worldwide distribution.

SIT (Clade), octal number spoligotype description	Total (%); in this study	% in this study versus database	Distribution in regions with ≥5% of a given SIT	Distribution in countries with ≥5% of a given SIT
	2 (2.2)	0.19	AFRI-S 31.46, AMER-S 21.68, AMER-N 15.78, EURO-S 13.36, EURO-W 5.32	ZAF 31.46,; USA 15.39,; BRA 8.81,; ESP 8.62,; ARG 5.52,; PER 5.42
	12 (13.3)	0.44	AMER-S 28.25, AMER-N 15.85, EURO-S 12.11, AFRI-N 10.44, EURO-W 6.65	USA 14.44,; BRA 9.78,; MAR 8.58,; COL 7.45,; ITA 6.36
	4 (4.4)	0.32	AMER-N 21.20, EURO-W 20.06, EURO-S 13.73, AMER-S 10.40, EURO-E 8.37	USA 19.33,; AUT 10.24,; ITA 7.23,; BRA 5.85
	2 (2.2)	1.46	AMER-N 21.90, EURO-N 21.17, EURO-W 13.14, AMER-S 12.41, EURO-S 10.95, AFRI-M 5.84	USA 18.98,; FIN 16.79,; PER 5.84,; AUT 5.11,; PRT 5.11,; FXX 5.11
	3 (3.3)	0.11	AMER-N 21.94, AMER-S 15.88, EURO-W 15.34, EURO-S 12.62, EURO-E 6.45, AFRI-N 5.16	USA 21.33,; AUT 7.38,; ESP 6.59,; ITA 5.27
	9 (10.0)	0.18	AMER-N 19.55, AMER-S 14.24, EURO-W 12.62, EURO-S 9.87, ASIA-W 8.55, AFRI-S 6.40	USA 17.05,; ZAF 6.26,; ITA 5.05
	3 (3.3)	2.59	AMER-N 68.10, CARI 17.24, AMER-S 5.17	USA 60.34,; MEX 7.76,; BHS 6.90,; HTI 6.90,; GUF 5.17
	4 (4.4)	0.39	AMER-N 70.10, AFRI-S 14.02	USA 61.76,; ZAF 14.02,; MEX 7.65
	2 (2.2)	50.00	ASIA-S 50.00, AMER-N 50.00	MEX 50.00,; IND 50.00
	2 (2.2)	14.29	EURO-S 35.71, ASIA-W 21.43, AMER-N 14.29, ASIA-SE 7.14, AMER-S 7.14, EURO-W 7.14, ASIA-E 7.14	ESP 28.57,; MEX 14.29,; TUR 14.29,; ITA 7.14,; NLD 7.14,; SAU 7.14,; TWN 7.14,; COL 7.14,; MYS 7.14
	2 (2.2)	100.00	AMER-N 100.00	MEX 100.00
	2 (2.2)	66.67	AMER-N 66.67, ASIA-W 33.33	MEX 66.67,; SAU 33.33

Worldwide distribution is reported for regions with ≥5% of a given SITs as compared to their total number in the SITVIT2 database. The definition of macrogeographical regions and subregions (http://unstats.un.org/unsd/methods/m49/m49regin.htm) is according to the United Nations; Regions: AFRI (Africa), AMER (Americas), ASIA (Asia), EURO (Europe), and OCE (Oceania), subdivided in: E (Eastern), M (Middle), C (Central), N (Northern), S (Southern), SE (South-Eastern), and W (Western). Furthermore, CARIB (Caribbean) belongs to Americas, while Oceania is subdivided in 4 subregions: AUST (Australasia), MEL (Melanesia), MIC (Micronesia), and POLY (Polynesia). Note that in our classification scheme, Russia has been attributed a new sub-region by itself (Northern Asia) instead of including it among rest of the Eastern Europe. It reflects its geographical localization as well as due to the similarity of specific TB genotypes circulating in Russia (a majority of Beijing genotypes) with those prevalent in Central, Eastern, and South-Eastern Asia.
The 3 letter country codes are according to http://en.wikipedia.org/wiki/ISO_3166-1_alpha-3; countrywide distribution is only shown for SITs with ≥5% of a given SITs as compared to their total number in the SITVIT2 database.