Tuberculous Meningitis: Diagnosis and Treatment Overview

Table 2

Pharmacokinetic activity and CSF penetration of anti-TB drugs.

	Anti-TB drug	Activity	CSF; penetration
1st-line; drugs	Isoniazid	Cidal	90%–95%
	Rifampin	Cidal	5%–25%
	Pyrazinamide	Cidal	95%–100%
	Streptomycin	Static	20%–25%
	Ethambutol	Static	10%–50%
	Ciprofloxacin	Cidal	15%–35%
	Levofloxacin	Cidal	60%–80%
	Moxifloxacin	Cidal	70%–80%
2nd-line drugs	Ethionamide	Cidal	80%–95%
	Cycloserine	Static	40%–70%
	Amikacin	Cidal	10%–25%
	Streptomycin	Cidal	10%–20%
	Capreomycin	Static	unknown
	Para-aminosalicylic acid	Static	unknown
	Thioacetazone	Static	unknown
	Linezolid	Cidal	80%–100%
New agents	Bedaquiline (TMC207)	Cidal	unknown
	Delamanid (OPC-67683)	Cidal	unknown

Cidal: bactericidal,
Static: bacteriostatic.