Stratified Threshold Values of QuantiFERON Assay for Diagnosing Tuberculosis Infection in Immunocompromised Populations
Table 3
Analysis of area under the receiver operating characteristic curves for lymphocyte-stratified patients groups.
Lymphocyte count/mm3
n
AUROC curve
95% CI
SE
cutoff value IU/mL
sensitivity %
95% CI
specificity %
95% CI
<300
45
0.86
0.777–0.943
0.04
0.04
80
65.4–90.4
86
81.7–89.2
300–500
57
0.82
0.806–0.938
0.03
0.04
79
66.1–88.6
86
81.7–89.2
500–700
79
0.93a
0.883–0.973
0.02
0.05
89
81.0–95.5
89
85.7–92.4
700–1000
145
0.97b
0.962–0.987
0.01
0.1
87
80.3–91.9
94
91.2–96.3
1000–1200
98
0.98b
0.957–0.994
0.01
0.1
91
83.3–95.7
94
91.2–96.3
1200–1500
121
0.97b
0.954–0.993
0.01
0.1
93
87.4–97.1
95
91.8–96.8
1500–1800
78
0.97b
0.949–0.989
0.01
0.15
91
82.4–96.3
96
93.2–97.6
>1800
104
0.99b
0.992–0.9997
0.002
0.19
96
90.4–98.9
98
96.0–99.2
Note. AUROC: area under the receiver operating characteristic; SE: standard error; CI: Confidence Interval Categories for lymphocyte counts exclude the value shown for the upper end of the range.
a: versus <300/mm3 category and versus 300–500/mm3 category.
b: versus <300/mm3 category, versus 300–500/mm3 category, and versus 500–700/mm3 category.