Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of <i>Mycobacterium tuberculosis</i>

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left" rowspan="2">Compounds</td><td align="center" rowspan="2">MIC<sub>90</sub>  (<i>μ</i>M)</td><td align="center" colspan="2">IC<sub>50</sub>  (<i>μ</i>M)</td></tr><tr><td align="center">VERO</td><td align="center">       MDBK</td></tr><tr><td align="center" colspan="4"><hr/></td></tr><tr><td align="left"><b>1</b></td><td align="center">159</td><td align="center">≥698</td><td align="center">≥698</td></tr><tr><td align="left"><b>2</b></td><td align="center">169</td><td align="center">≥706</td><td align="center">≥706</td></tr><tr><td align="left"><b>3</b></td><td align="center">62,4</td><td align="center">203</td><td align="center"><span style="width: 38.612499px;"><svg height="12.4875" id="M7" style="vertical-align:-1.29163pt" version="1.1" viewbox="0 0 38.612499 12.4875" width="38.612499" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">≥</tspan>
<tspan style="font-size: 12.50px; " x="12.027886" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="18.279387" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="24.530886" y="0">1</tspan>
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</svg></span></td></tr><tr><td align="left"><b>4</b></td><td align="center">6,09</td><td align="center">—</td><td align="center">367</td></tr><tr><td align="left"><b>5</b></td><td align="center">81.1</td><td align="center">—</td><td align="center">9,34<svg height="8.7875004" id="M8" style="vertical-align:-0.3135pt" version="1.1" viewbox="0 0 20.549999 8.7875004" width="20.549999" xmlns="http://www.w3.org/2000/svg">
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</svg>10<sup>-2</sup></td></tr><tr><td align="left"><i>Isoniazid</i></td><td align="center">0,438</td><td align="center">—</td><td align="center">—</td></tr><tr><td align="left"><i>Rifampin</i></td><td align="center">0,608</td><td align="center">—</td><td align="center">—</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Antimycobacterial and cytotoxicity of lignans and oxadiazolines.

Tuberculosis Research and Treatment

tab1

Table 1

Table 1: Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of <i>Mycobacterium tuberculosis</i> 

Tuberculosis Research and Treatment

Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis

Table 1