Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones

Table 4

In vivo efficacy and observation at time of sacrifice.

Compd.	Lungs	Spleen	Other remarks
Control	+++	6 enlarged; 1 very large	2 with enlarged lymph nodes
INH	+	1 slightly enlarged; 4 normal	n/a
2l (306019)	++	1 enlarged; 4 slightly enlarged	Large intestine distended full of feces and air
1g (306027)	+	1 slightly enlarged; 4 normal	Large intestine distended full of feces and air
PH-27 (306006)	+	normal	Large intestine distended full of feces and air

+++; highly infected. ++/+; hardly any infected. n/a; not applicable.