The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis

Table 1

(a) Median and range for patient age and IGRA test result for all culture positive cases of active tuberculosis, by organ manifestation. (b) Median and range for age and IGRA test result for all controls, by diagnosis. “Others” includes other lung diseases such as asbestosis, aspergillosis, asthma, bronchiectasis, pleural effusion, haemoptysis, fibrosis, and sarcoidosis. (c) Study results for TB cases and controls. (𝑛: sample size, CI: confidence interval).

(a)

MTB infection	Male	Female	Total	Median age, years (range)	Median QFT, IU/mL (range)
Lung	28	25	53	45 (4–83)	2.40 (0,00–103,4)
Pleura	2	3	5	26 (17–76)	2,45 (0,96–300)
Lymph node	2	1	3	65 (25–69)	21,32 (3,78–86,8)
Total	32	29	61	46 (5–84)	3.46 (0,00–300)

(b)

Diagnosis	Male	Female	Total	Median age, years (range)	Median QFT, IU/mL (range)
Malignancy	22	23	45	69 (39–90)	0,01 (0,00–23,9)
Bronchitis	27	13	40	64 (1–90)	0,00 (0,00–1,84)
Pneumonia	30	17	47	67 (1–99)	0,00 (0,00–75)
Others	53	49	102	62,5 (5–99)	0,02 (0,00–103,4)
Total	132	102	234	66 (1–99)	0,00 (0,00–103,4)

(c)

	𝑛	QFT			Age
		Mean	95% CI	𝑃	Mean	95% CI	𝑃
TB	61	14.13	3.44–24.82	<0.05	47.8	41.88–53.79	<0.05
Control	234	1.33	0.24–2.43		63	60.56–65.39