Early Therapeutic Drug Monitoring for Isoniazid and Rifampin among Diabetics with Newly Diagnosed Tuberculosis in Virginia, USA

Table 1

Baseline characteristics of adults with drug-susceptible tuberculosis referred for therapeutic drug monitoring (TDM) based on slow response or early TDM if diabetic.

Characteristic	Diabetes; (early TDM); 𝑁=21	Slow response; (standard TDM); 𝑁=14	𝑃 value
Age, mean years ± SD	57±17	46±12	𝑃=0.04
Gender, male (%N)	15 (71)	11 (79)	𝑃=0.69
Prior episode of TB, n (%N)	0	2 (14)	𝑃=0.17
Pulmonary TB only, n (%N)	17 (81)	8 (57)	𝑃=0.65
Foreign born (%N with confirmed status*)	15 (79)	12 (92)	𝑃=0.63
HIV infected (%N with confirmed status*)	0	1 (11)	𝑃=0.43
Insulin dependence, n (%N)	10 (48)	N/A	N/A
Days to TDM from treatment initiation, median days (IQR)	23±16	88±54	𝑃=0.003

Slow response patients did not include diabetics (see Figure 1).*Missing values include foreign born status in 2 diabetics and 1 patient with slow response and HIV status in 4 patients with slow response. N/A: not applicable.