Mefloquine and Its Enantiomers Are Active against Mycobacterium tuberculosis In Vitro and in Macrophages

Table 3

Activity of mefloquine and (+)erythro-mefloquine in conditions of hyperosmolarity and acidic pH.

MIC (mcg/mL)
	Mefloquine			(+)Erythro-mefloquine
	7H9	7H9 pH 5.5	7H9 0.3 M	7H9	7H9 pH 5.5	7H9 0.3 M
H37Rv	8	8	32	8	8	32
Ederman	8	8	16	8	8	16

Bacteria were incubated with antibiotic in 7H9 broth, 7H9 + pH 5.5, and 7H9 + 0.3 M of dextrose.