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Tuberculosis Research and Treatment
Volume 2014, Article ID 624671, 6 pages
http://dx.doi.org/10.1155/2014/624671
Clinical Study

Prognostic Factors in Tuberculosis Related Mortalities in Hospitalized Patients

Department of Chest Medicine, Jinnah Postgraduate Medical Centre, Rafiqui H J Shaheed Road, Karachi 75510, Pakistan

Received 28 January 2014; Accepted 13 April 2014; Published 7 May 2014

Academic Editor: José R. Lapa e Silva

Copyright © 2014 Ghazal Haque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Setting. The study was undertaken at the Department of Pulmonology at a public, tertiary care centre in Karachi, Pakistan. Objectives. To evaluate factors concerned with in-hospital deaths in patients admitted with pulmonary tuberculosis (TB). Design. A retrospective case-control audit was performed for 120 patients hospitalised with pulmonary TB. Sixty of those discharged after treatment were compared to sixty who did not survive. Radiological findings, clinical indicators, and laboratory values were compared between the two groups to identify factors related to poor prognosis. Results. Factors concerned with in-hospital mortality listed late presentation of disease ( ), noncompliance to antituberculosis therapy ( ), smoking ( ), longer duration of illness prior to treatment ( ), and low body weight ( ). Most deaths occurred during the first week of admission ( ) indicating late referrals as significant. Immunocompromised status and multi-drug resistance were not implicated in higher mortality. Conclusions. Poor prognosis was associated with noncompliance to therapy resulting in longer duration of illness, late patient referrals to care centres, and development of complications. Early diagnosis, timely referrals, and monitored compliance may help reduce mortality. Adherence to a more radically effective treatment regimen is required to eliminate TB early during disease onset.