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Tuberculosis Research and Treatment
Volume 2016, Article ID 1468631, 7 pages
Research Article

Characteristics and Treatment Outcomes of Retreatment Tuberculosis Patients in Benin

1National Tuberculosis Programme, 01 BP 321 Cotonou, Benin
2Faculté de Médecine, Université de Parakou, Parakou, Benin
3International Union against Tuberculosis and Lung Disease, Paris, France
4London School of Hygiene & Tropical Medicine, London, UK

Received 30 December 2015; Accepted 9 March 2016

Academic Editor: Isamu Sugawara

Copyright © 2016 Serge Ade et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To determine among retreatment tuberculosis patients in Benin baseline characteristics, culture, and drug sensitivity testing (DST) results and treatment outcomes. Materials and Methods. A retrospective national cohort study of all retreatment tuberculosis patients in Benin in 2013 using registers and treatment cards. Results. Of 3957 patients with tuberculosis, 241 (6%) were retreatment cases. Compared to new pulmonary bacteriologically confirmed tuberculosis (NPBCT) patients, there were significantly higher numbers of males (), patients from “Atlantique-Littoral” (), patients aged 45–64 years (), and HIV-positive patients () among those retreated. Overall, 171 (71%) patients submitted sputum for DST, of whom (163) 95% were positive for Mycobacterium tuberculosis on Xpert MTB/RIF and/or culture and 17 (10%) were rifampicin resistant (9 with MDR-TB and 8 monoresistant to rifampicin). For those without MDR-TB (), treatment success was 93%. Worse outcomes occurred in those with unknown HIV status (RR: 0.27; 0.05–1.45; ) while better outcomes occurred in those who relapsed (RR: 1.06, 95 CI: 1.02–1.10, ). Conclusion. In 2013, a high proportion of retreatment patients received DST. Treatment success was good although more needs to be done to systematically increase the final follow-up smear examination. Reasons of high losses to follow-up from “Oueme-Plateau” should be investigated.