Tuberculosis Research and Treatment / 2016 / Article / Tab 2

Research Article

Molecular and Growth-Based Drug Susceptibility Testing of Mycobacterium tuberculosis Complex for Ethambutol Resistance in the United States

Table 2

Cross-tabulation of CDC’s molecular detection with both PHL and CDC growth-based DST results for determination of EMB resistance.

Detection of embB mutation by CDC’s MDDRNumber of samplesNumber of EMB-resistant MTBC samples (%) value
PHL growth-based DSTCDC agar proportion

Yes3923 (59.0)33 (84.6)0.002
No1317 (5.34)10 (7.63)0.317

Total17030 (17.6)43 (25.3)0.003

Including samples with Glu378Ala and Leu355Leu polymorphisms not associated with EMB resistance.
CDC: Centers for Disease Control and Prevention; PHL: public health laboratory; DST: drug susceptibility testing; EMB: ethambutol; MTBC: Mycobacterium tuberculosis complex; MDDR: molecular detection of drug resistance.

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