Direct observation of treatment intake is required and always in regimen including rifampicin. ¥Streptomycin may be used instead of ethambutol. In meningitis, ethambutol should be replaced by streptomycin. ªIn children with meningitis, add streptomycin in the initial phase. Codes for Tb drugs: H: isoniazid; R: rifampicin; Z: pyrazinamide; S: streptomycin; E: ethambutol. Fixed drug combinations (FDC) codes: (HR): isoniazid + rifampicin; (HRZ): isoniazid + rifampicin + pyrazinamide; (HRZE): isoniazid + rifampicin + pyrazinamide + ethambutol.