Tuberculosis Research and Treatment

Tuberculosis Diagnostics in the New Millennium: Role in TB Identification and Control

Publishing date
25 May 2012
Submission deadline
25 Nov 2011

1Division of Infectious Diseases, Department of Medicine, New Jersey Medical School, University of Medicine & Dentistry of New Jersey, Newark, NJ 07103, USA

2Foundation for Innovative New Diagnostics (FIND), Avenue de Budé 16, 1202 Geneva, Switzerland

3Department of Microbiology, International Tuberculosis Research Center, Changwon, Gyeongsang, Republic of Korea

Tuberculosis Diagnostics in the New Millennium: Role in TB Identification and Control


Tuberculosis (TB) continues to be a threat to the world with nearly 1.7 million deaths in 2009. No new effective anti-TB drugs have been discovered in the last four decades and TB strains have become increasingly resistant to the existing drugs, resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB. In the absence of new drugs, currently the focus is on definitive new age molecular diagnostics of drug susceptible as well as MDR and XDR TB. Recently, considerable attention has been paid to developing such new age diagnostics. These tests are expected to replace the outdated smear microscopy and culture methods that result in delayed and insensitive diagnostics, thereby impairing TB control programs. Furthermore, the high rate of association of HIV with TB renders smear microscopy ineffective. Promising new diagnostic technologies like the Xpert-MTB Rif assays have been endorsed by the WHO recently. However, search is still on for a “one-size-fits-all” technology that can reliably replace smear microscopy and culture techniques without prohibitively increasing cost or operational complexity.

We invite investigators to submit original research as well as review articles on new diagnostic approaches of tuberculosis which has the potential to enable faster, more sensitive and specific diagnosis and are expected to have a positive impact on health care and TB control systems of the disease endemic countries. Potential topics include, but are not limited to:

  • Development and testing of novel diagnostic techniques for both pulmonary and extrapulmonary tuberculosis
  • Identification of new diagnostic biomarkers for rapid, specific, and sensitive identification of Mycobacterium tuberculosis
  • Development of novel serodiagnostic strategies for pulmonary and extrapulmonary tuberculosis
  • Development of tuberculosis diagnostic modalities which show increased sensitivity in HIV positive settings
  • Identification of novel gene mutations for molecular drug susceptibility testing for MDR and XDR tuberculosis and developing rapid assays using the same
  • New diagnostic technologies as surveillance tools in diseased population and effect on TB control programs if any
  • Studies on the effect of new diagnostic technologies on patient treatment outcome and impact on TB control programs

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2012
  • - Article ID 768603
  • - Editorial

Tuberculosis Diagnostics in the New Millennium: Role in TB Identification and Control

Soumitesh Chakravorty | Catharina Boehme | Jongseok Lee
  • Special Issue
  • - Volume 2012
  • - Article ID 716989
  • - Clinical Study

Pouched Rats’ Detection of Tuberculosis in Human Sputum: Comparison to Culturing and Polymerase Chain Reaction

Amanda Mahoney | Bart J. Weetjens | ... | Alan Poling
  • Special Issue
  • - Volume 2012
  • - Article ID 831292
  • - Review Article

The PCR-Based Diagnosis of Central Nervous System Tuberculosis: Up to Date

Teruyuki Takahashi | Masato Tamura | Toshiaki Takasu
  • Special Issue
  • - Volume 2012
  • - Article ID 345290
  • - Clinical Study

Maintenance of Sensitivity of the T-SPOT.TB Assay after Overnight Storage of Blood Samples, Dar es Salaam, Tanzania

Elizabeth A. Talbot | Isaac Maro | ... | C. Fordham von Reyn
  • Special Issue
  • - Volume 2012
  • - Article ID 768723
  • - Clinical Study

The Use of Interferon Gamma Release Assays in the Diagnosis of Active Tuberculosis

Silvan M. Vesenbeckh | Nicolas Schönfeld | ... | Holger Rüssmann
  • Special Issue
  • - Volume 2012
  • - Article ID 128057
  • - Clinical Study

Comparison of Overnight Pooled and Standard Sputum Collection Method for Patients with Suspected Pulmonary Tuberculosis in Northern Tanzania

Stellah G. Mpagama | Charles Mtabho | ... | Gibson S. Kibiki
Tuberculosis Research and Treatment
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