Table of Contents
Ulcers
Volume 2011, Article ID 214124, 9 pages
http://dx.doi.org/10.1155/2011/214124
Research Article

Influence of Cord Blood Fraction (below 5 kDa) on Reparative Processes during Subchronic Ulcerative Gastropathy

Institute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of Ukraine, Pereyaslavskaya Street 23, Kharkov 61015, Ukraine

Received 30 March 2011; Revised 4 July 2011; Accepted 4 July 2011

Academic Editor: Gyula Mozsik

Copyright © 2011 Alexander Kirillovich Gulevsky et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The low molecular fraction (below 5 kDa) was extracted from cord blood by ultrafiltration. It has been shown that the cord blood fraction possesses antiulcer activity on the model subchronic stomach ulcer. The cord blood fraction injections caused a significant reduction in the area of ulcer lesions and promoted recovery of microcirculation, thickness, and structure of gland layer, which was accompanied by a decrease in leucocytes infiltration and an increase in glycosaminoglycans synthesis. That resulted in a faster recovery of mucus membrane of stomach as compared with Actovegin. Application of the cord blood fraction in animals with stomach ulcer normalized the alkaline phosphatase activity and thiobarbituric acid-active product content. Gel-penetrating chromatography showed that the patterns of the low molecular substances from cord blood and Actovegin differed both qualitatively and quantitatively.