Table of Contents
Volume 2012, Article ID 767861, 7 pages
Research Article

Stratification of Highest-Risk Patients with Chronic Skin Ulcers in a Stanford Retrospective Cohort Includes Diabetes, Need for Systemic Antibiotics, and Albumin Levels

1Department of Dermatology, Stanford University School of Medicine, Pavilion C, 2nd floor, 450 Broadway Street, MC 5334, Redwood City, CA 94063, USA
2Department of Medicine, Albert Einstein College of Medicine, 1925 Eastchester Road 15A, Bronx, New York City, NY 10461, USA

Received 31 July 2012; Accepted 10 September 2012

Academic Editor: Marco A. C. Frade

Copyright © 2012 Omar Amir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic nonsurgical skin wounds such as venous stasis and diabetic ulcers have been associated with a number of comorbid conditions; however, the strength of these associations has not been compared. We utilized the Stanford Translational Research Integrated Database Environment (STRIDE) system to identify a cohort of 637 patients with chronic skin ulcers. Preliminary analysis ( ) showed that 49.7% of the patients had a poor prognosis such as amputation or a nonhealing ulcer for at least a year. Factors significantly associated ( ) with these outcomes included diabetes mellitus, chronic kidney disease, peripheral neuropathy, peripheral arterial disease, and need for systemic antibiotics. Patients with poor outcomes also tended to have lower hemoglobin levels ( ), higher WBC levels ( ), and lower albumin levels ( ). On multivariate analysis, however, only diabetes mellitus (OR 5.87, 1.36–25.3), need for systemic antibiotics (OR 3.88, 1.06–14.2), and albumin levels (0.20 per unit, 0.07–0.60) remained significant independent predictors of poor wound-healing outcomes. These data identify patients at the highest risk for poor wound-healing and who may benefit the most from more aggressive wound care and treatment.