Gastroprotective Efficacy of Coenzyme Q10 in Indomethacin-Induced Gastropathy: Other Potential Mechanisms

Table 2

Effect of L-NAME (50 mg/kg; i.p.) on gastroprotection by 200 mg/kg coenzyme Q10 (CoQ10-200; p.o.) and 20 mg/kg pantoprazole (PANTO-20; p.o.) on ulcer number, ulcer index, and gastric mucosal nitric oxide (NO) content in indomethacin (INDO; 20 mg/kg, i.p.) induced gastric injury.

Groups	Parameters
	Ulcer number	Ulcer index	Gastric mucosal NO
	(Median (minimum-maximum))	(mm)	(μM/g tissue)
CONT (vehicle)	0.0 (0-0)	0.0±0	862.7±28.38
INDO	7.5* (5-9)	10.3*±1.50	704.2*±35.19
PANTO-20	2.5 (2-3)	2.7^*@±0.33	877.2^@±29.42^@
L-NAME + PANTO-20 + INDO	4.0* (3-6)	5.0^*@±0.37	703.9^*#±7.74
CoQ10-200	2.5 (2-3)	3.3^*@±0.33	812.7^@±29.18
L-NAME + CoQ10-200 + INDO	3.5* (3-4)	4^*@±0.26	701.1^*†±5.63

For ulcer number, values are median of 6–10 rats and statistical analysis was performed using Kruskal-Wallis test (nonparametric ANOVA) followed by Dunn’s Multiple Comparisons Test, 𝑃<0.05. For ulcer index and gastric mucosal NO, values are means ± S.E.M. of 6–10 rats; comparisons were carried out using one-way ANOVA followed by Student-Newman-Keuls Multiple Comparisons Test, 𝑃<0.05. As compared to control (CONT) (*), INDO (^@), PANTO-20 (^#), and CoQ10-200 (^†).