Ulcers

Ulcers / 2013 / Article / Tab 3

Research Article

Antioxidant Capacity, Cytoprotection, and Healing Actions of the Leaf Aqueous Extract of Ocimum suave in Rats Subjected to Chronic and Cold-Restraint Stress Ulcers

Table 3

Healing effect of the leaf aqueous extract of O. suave on chronic acetic acid-induced gastric ulcers in rats.

TreatmentExtracted dose (mg/kg) Ulcerated area (mm2)% HealingMucus production (mg)Stomach relative weight (%)

Healthy control60
Group 16
Group 26 41.9
Group 31256 84.5**
Group 42506 91.4**
Group 55006 93.2**
Group 6 (ranitidine)506 80.4**

: number of rats.
Statistically different relative to group 2, .
Statistically different relative to group 1, .
Healthy control: healthy, nonulcerated control rats.
Group 1 (ulcerated rats sacrificed 4 days after acetic acid ulcer induction), showing a deep large ulcer (about 81 mm2), with raised edges and sclerous interior.
Group 2 (ulcerated rats given vehicle for 14 days following ulcer induction).
Groups 3, 4, and 5 ulcerated rats treated with 125, 250, and 500 mg/kg bw of extract, respectively, for 14 d after day 4 of ulcer establishment.
Positive control rat given ranitidine (50 mg/kg bw) for 14 d after ulcer establishment.