Table of Contents
Volume 2013, Article ID 714807, 7 pages
Review Article

Accumulation of Mast Cells in the Lesions and Effects of Antiallergic Drugs on the Patients with Inflammatory Bowel Disease

1Department of Allergy and Respiratory Medicine, Tatebayashi-Kosei Hospital, 262-1 Narushima, Tatebayashi, Gunma 374-8533, Japan
2Gifu Junior College of Health Science, 2-92 Higashi-uzura, Gifu 500-8281, Japan

Received 22 September 2012; Revised 14 April 2013; Accepted 17 April 2013

Academic Editor: Aleem Ahmed Khan

Copyright © 2013 Motohiro Kurosawa and Hiroichi Nagai. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The pathomechanism of inflammatory bowel disease (IBD) has not yet been fully demonstrated. However, it is well known that mast cells are present in the gastrointestinal tract, suggesting that mast cells may take part in it. So, we investigated the number of mast cells in IBD, such as ulcerative colitis (UC) and eosinophilic colitis, and showed that the number of mast cells was increased in the inflammatory lesions. We also presented a case of UC which was treated successfully with an antiallergic drug, tranilast. Furthermore, possible new approaches to treating the disease with immunomodulators including suplatast are introduced. However, our investigations were performed with a limited number of patients with IBD, and additional further studies are required to confirm the findings.