Antiulcerogenic Activity of 1-Hydroxy-3,7,8-trimethoxyxanthone Isolated from the Methanol Extract of Anthocleista vogelii PLANCH. in Rats
Table 1
Effect of the ten fractions of the methanol extract of A. vogelii and 1-hydroxy 3,7,8-trimethoxyxanthone (AV) on HCl/ethanol-induced gastric lesions in rats.
Treatment
Dose (mg/kg)
US area (mm²)
Ulcer index
% US
% I
Mucus weight (mg)
Distilled water
6
—
132.61 ± 24.70
5.49 ± 0.98
22.02
—
51.00 ± 0.46
Cimetidine
6
12
92.82 ± 16.62
5.57 ± 0.76
13.78
29.84
61.00 ± 0.83
Sucralfate
6
50
36.87 ± 25.14b
3.46 ± 1.75
4.82
72.20
78.00 ± 0.96b
6
100
25.21 ± 4.26b
3.72 ± 0.38a
3.80
80.99
85.00 ± 1.20b
6
100
50.21 ± 11.51b
4.45 ± 0.74
6.11
61.51
100.00 ± 3.79b
6
100
48.12 ± 11.04b
3.89 ± 0.46a
6.59
63.71
98.00 ± 4.62b
6
100
22.27 ± 15.20b
2.83 ± 1.39b
3.18
83.21
116.00 ± 7.89b
6
100
38.61 ± 16.82b
3.07 ± 0.72 b
5.00
70.88
100.00 ± 4.59b
6
100
44.73 ± 21.45b
3.73 ± 0.42b
5.71
66.27
95.00 ± 2.60b
6
100
29.40 ± 14.37b
3.09 ± 0.31b
3.84
77.84
104.00 ± 5.62b
6
100
101.65 ± 18.24
5.28 ± 0.77
1.46
23.35
65.00 ± 4.82
6
100
36.19 ± 17.05b
3.52 ± 0.68b
4.57
72.71
101.00 ± 7.20b
6
100
18.43 ± 6.43b
3.10 ± 0.63b
2.47
86.10
106.00 ± 6.05b
6
100
50.90 ± 17.50b
3.58 ± 0.47a
6.41
61.62
88.00 ± 4.39b
AV
6
1
51.85 ± 4.83b
4.87 ± 0.80
8.31
60.90
55.00 ± 0.56
AV
6
2
8.99 ± 5.77b
2.32 ± 1.26b
1.40
93.22
115.00 ± 2.21b
AV
6
5
14.62 ± 1.27b
2.86 ± 0.30b
2.22
88.98
90.00 ± 1.13b
= number of rats per group. I = inhibition. US = ulcer surface. ; 0.01 statistically significant relative to negative control (distilled water).